Christer Betsholtz Selected Research

Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)

11/2021	Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development.
1/2021	The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression.
11/2020	Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis.
1/2015	Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.
12/2013	Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
4/2004	Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
1/2004	Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

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Christer Betsholtz Research Topics

Disease

15	Neoplasms (Cancer) 12/2022 - 01/2002
6	Inflammation (Inflammations) 01/2022 - 01/2016
5	Proteinuria 06/2022 - 08/2003
5	Hypoxia (Hypoxemia) 01/2020 - 10/2003
5	Fibrosis (Cirrhosis) 01/2018 - 01/2009
4	Neoplasm Metastasis (Metastasis) 11/2020 - 03/2006
4	Atherosclerosis 08/2016 - 10/2002
3	IGA Glomerulonephritis (IGA Nephropathy) 06/2022 - 10/2017
3	Neuroinflammatory Diseases 01/2022 - 01/2011
3	Albuminuria 01/2021 - 01/2011
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 01/2015
2	Glioma (Gliomas) 12/2022 - 01/2019
2	Infections 06/2022 - 02/2021
2	Hemorrhage 06/2022 - 11/2021
2	Pathologic Processes 01/2022 - 01/2013
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 05/2012
2	Stroke (Strokes) 01/2021 - 01/2011
2	Melanoma (Melanoma, Malignant) 11/2020 - 01/2009
2	Brain Neoplasms (Brain Tumor) 01/2020 - 01/2011
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2017 - 08/2016
2	Emphysema 04/2016 - 01/2015
2	Brain Diseases (Brain Disorder) 07/2014 - 01/2011
2	Ischemia 01/2013 - 07/2008
2	Alzheimer Disease (Alzheimer's Disease) 05/2012 - 02/2007
2	Diabetic Retinopathy (Retinopathy, Diabetic) 08/2011 - 08/2002
2	Diabetic Angiopathies (Diabetic Angiopathy) 04/2004 - 01/2004
1	Disease Progression 06/2022
1	Critical Illness (Critically Ill) 06/2022
1	COVID-19 06/2022
1	Central Nervous System Diseases (CNS Diseases) 01/2022
1	Arthritis (Polyarthritis) 01/2022
1	Experimental Arthritis 01/2022
1	Rheumatoid Arthritis 01/2022
1	Epilepsy (Aura) 01/2022
1	Glomerulonephritis 01/2022
1	Osteoarthritis 01/2022
1	Schizophrenia (Dementia Praecox) 01/2022
1	Seizures (Absence Seizure) 01/2022
1	Myofibromatosis 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Coronary Occlusion 01/2021
1	Myocardial Infarction 01/2021
1	Circulating Neoplastic Cells 01/2020
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2019

Drug/Important Bio-Agent (IBA)

10	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 01/2020 - 08/2002
7	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 11/2021 - 01/2004
7	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 01/2021 - 10/2002
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2017 - 10/2002
4	Proteins (Proteins, Gene)FDA Link 12/2022 - 11/2012
4	platelet-derived growth factor C (PDGF-C)IBA 04/2016 - 07/2008
4	Platelet-Derived Growth FactorIBA 01/2009 - 10/2002
3	RNA (Ribonucleic Acid)IBA 01/2022 - 08/2016
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2009
3	LigandsIBA 01/2021 - 01/2018
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 01/2009
3	LipidsIBA 01/2019 - 08/2016
3	Protein Isoforms (Isoforms)IBA 12/2016 - 01/2007
3	Retinaldehyde (Retinal)IBA 01/2007 - 08/2003
2	AntibodiesIBA 12/2022 - 10/2009
2	CytokinesIBA 06/2022 - 01/2022
2	Semaphorins (Semaphorin)IBA 01/2022 - 01/2016
2	Antigen-Antibody Complex (Immune Complex)IBA 01/2022 - 10/2017
2	Immunoglobulin A (IgA)IBA 01/2022 - 10/2017
2	CollagenIBA 01/2022 - 10/2009
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2021 - 07/2008
2	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2019
2	Messenger RNA (mRNA)IBA 01/2018 - 09/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2018 - 06/2010
2	platelet-derived growth factor AIBA 12/2016 - 01/2016
2	LipopolysaccharidesIBA 01/2016 - 01/2009
2	IntegrinsIBA 12/2013 - 10/2009
2	Apolipoproteins E (ApoE)IBA 09/2005 - 10/2002
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2022
1	dendrinIBA 06/2022
1	Angiopoietin-2IBA 06/2022
1	ThrombomodulinIBA 06/2022
1	TIE-2 Receptor (Receptor, TIE 2)IBA 06/2022
1	RepSoxIBA 01/2022
1	Adenosine Triphosphate (ATP)IBA 01/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	Kainic Acid (Kainate)IBA 01/2022
1	Methotrexate (Mexate)FDA LinkGeneric 01/2022
1	Neuropilin-2IBA 01/2022
1	KATP ChannelsIBA 01/2022
1	Claudin-5IBA 01/2022
1	Angiotensin-Converting Enzyme 2IBA 02/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Collagen Type I (Type I Collagen)IBA 01/2021
1	Vascular Endothelial Growth Factor BIBA 01/2021
1	Small Cytoplasmic RNAIBA 01/2021
1	IgA receptor (protein B)IBA 11/2020
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2020
1	calcium phosphateIBA 01/2020
1	Cholesterol 24-Hydroxylase (CYP46A1)IBA 12/2019
1	Lipoproteins (Lipoprotein)IBA 01/2019

Therapy/Procedure

8	Therapeutics 12/2022 - 05/2009
1	Immunotherapy 12/2022
1	Thrombolytic Therapy 01/2021
1	Cranial Irradiation 01/2020